التأثري املضبد لاللتهبة ملستخلصبت قشىر وبذور الزمبن على أرجل فئزان التجبرة

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1 التأثري املضبد لاللتهبة ملستخلصبت قشىر وبذور الزمبن على أرجل فئزان التجبرة ١

2 اخلالصة ٢

3 املقدمة: (4, 3, 2, 1 ٣

4 منهج البحث -1-2 ٤

5 -3 400, 200, 100 P<0.05 (Mean ±SEM) t-test ٥

6 النتائج , 200, , 200, , 200, ٦

7 املناقشه (5, 2, 1) (7) 6 ٧

8 (8) ccl 4 (11, 12). (10, 9).(16, 15, 14, 13) (High pressure liquid chromatography) ٨

9 ± v ± ± 0.06 _ ± ± ± ± % ± ± ± ± ± ± ± ± ± ± ± ± % - 33 % - 37 % ± ± ± ± ± ± ± ± ± ± ± ± % - 51 % - 55 % ± ± ± ± ± ± ± ± ± ± ± ± % + 1 % + 9 % (P<0.05) ٩

10 ± ± ± ± 0.06 _ ± ± ± ± % ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± % + 3 % + 9 % - 33 % - 40 % - 60 % + 5 % + 4 % + 7 % (P<0.05) ١٠

11 References 1- Ames, B.N., Dietary carcinogens and anticarcinogene: oxygen radicals and degenerative diseases. Science 221, Halliwell, B., Gutteridge, J.M.C., Cross, C.E., Antioxidant and human disease: where are we?. J. Lab. and Clinical Med. 119, Kim, S.B., Kim, I.S., Yeum, D.M., Park, Y.H., Mutagenicity of Maillard reaction products from D-glucoseamino acid mixtures and possible roles of active oxygen in mutagenicity. Mutation Research 254, Ueno, H., Nakamuro, K., Sayato, Y., Okada, S., Characteristics of mutagenesis by glyoxal in Salmonella typhimurium: contribution of singlet oxygen. Mutation Res. 251, Hodnick, W.F., Kung, F.S., Roetger, C.W., Bohmont, C.W., Pardini, R., Inhibition of mitochondrial oxidation and production of toxic oxygen radicals by flavonoids: a structure activity study. Biochemical Pharmacology 35, Ames, B.N., Shigenaga M.K., Hage, T.M., Oxidative antioxidant and degenerative disease of aging. Proceeding of the national Academy of Science USA. 90, ١١

12 7- Kim, N.D., Mehta, R., Yu, W., Neeman, I., Livney, T., Amichay, et. al Chemoprevention and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res. Treat. 71(3), Kotamballi, N., Chidambra, M., Guddadarangavvhally, K., Ravendra, P.S., Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo model. J. Agric. Food Chem. 50(17), Harborne, J.B., the anthocyanin pigments. In comparative Biochemistry of the Flavonoids; Academic Press: New York, 1967; Noda, Y., Kaneyuki, T., Mori, A., Packer, L., Antioxidant activities of pomegranate fruit extract and its anthcyanidins: delphinidin, cyaniding and pelargonidin. J. Agr. Food Chem., 50(1), Gaziano, J.M., Manson, J.E., Branch, L. G., Golditz, G.A., Willett, W.C., Buring, J.E., Prospective study of consumption of cartenoids in fruits and vegetables and decreased cardiovascular mortality in the elderly. Ann. Epidemiol., 5, Naser, C.B., Ayed, N., Meche, M., Quantitative determination of the polyphenolic content of pomegranate peel. Zeit. Leben. Unterch. Forsch. 203, ١٢

13 13- Gill, M.I., Tomas-Barberan, F.A., Hess Pierce, B., Holcroft, D.M., Kader, A.A., Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J. Agricultural & Food chemistry 48, Aviram, M., Dorafeld, L., Rosenblat, M., Volkova, N., Kaplan, M., Coleman, R., et. Al pomegranate juice consumption reduced oxidative stress, atherogenic modification to LDL and platelets aggregation : studies in human and in atherosclerotic apolipoprotien E-deficient mince. Am. J. Clinical Nutr. 71, Kaplan, M., Hayek, T., Raz, A., Coleman, R., pomegranate juice supplementation to atheroscelerotic mice reduces macrophages lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J. Nut., 131, Aviram, M., Dornfeld, L., Rosenblat, M., Volkova, N., Kaplan, M., Coleman, R., et. al Pomegranate juice consumption reduces oxidative stress, atherogenic modification to LDL, and platelets aggregation: studies in human and in atherosclerotic apolipoprotein E-deficient mice. Am. J. Clinical Neut. 71(5), ١٣